SITE DIRECTED MODIFICATION OF FVIII

PROBLEM TO BE SOLVED: To provide a biocompatible polymer-conjugated functional FVIII polypeptide having improved pharmacokinetic characteristics and therapeutic characteristics.SOLUTION: An isolated polypeptide conjugate having factor VIII procoagulant activity comprises a functional factor VIII pol...

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Bibliographic Details
Main Authors STRAUSS JONATHAN S, TJANDRA HENDRI, BARNETT THOMAS, CHEN JIANMIN, MEI BAISONG, WANG DEQIAN, MURPHY JOHN E, PAN CLARK Q, TANG LIANG
Format Patent
LanguageEnglish
Japanese
Published 08.06.2017
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a biocompatible polymer-conjugated functional FVIII polypeptide having improved pharmacokinetic characteristics and therapeutic characteristics.SOLUTION: An isolated polypeptide conjugate having factor VIII procoagulant activity comprises a functional factor VIII polypeptide having heavy and light chains. The functional factor VIII polypeptide is covalently bound to one or more biocompatible polymers only in the heavy chain.SELECTED DRAWING: None 【課題】向上した薬物動態学的特性及び治療的特性を有する生物適合性ポリマー−複合機能性ＦＶＩＩＩポリペプチドを提供する。【解決手段】因子ＶＩＩＩプロコアグラント活性を有する単離されたポリペプチド複合体であって、重鎖および軽鎖を有する機能性因子ＶＩＩＩポリペプチドを含んでなり、該機能性因子ＶＩＩＩポリペプチドが重鎖のみにおいて１個もしくはそれ以上の生物適合性ポリマーに共有結合している、上記単離されたポリペプチド複合体。【選択図】なし
Bibliography:Application Number: JP20160234756