METHOD FOR PRODUCING OPTICALLY ACTIVE TETRAHYDROQUINOLINES

• Main Authors: MIYAWAKI TOSHIO, MAEDA SADAYUKI, SATO TATSUNORI, KAWANO YASUHIKO
• Format: Patent
• Language: English; Japanese
• Published: 01.06.2017
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

PROBLEM TO BE SOLVED: To provide a novel chiral iridium (III) complex, which is used for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines.SOLUTION: Provided is an iridium (III) complex having a chiral proline amide compound represented by formula (IV) as a ligand. (X is Cl-, p-CH3C6H4SO3-, CH3SO3-, CF3SO3-, NO3-, BF4-, ClO4-, PF6-, SbF6-, B[3,5-di(trifluoromethyl)phenyl]4- or B(4-fluorophenyl)4-; L is a proline amide compound; and Cp* is (1,2,3,4,5-η)-pentamethyl-2,4-cyclopentadien-1-yl.)SELECTED DRAWING: Figure 1 【課題】光学活性２−置換-１，２，３，４−テトラヒドロキノリン類の製造に用いるキラルな新規イリジウム（III）錯体の提供。【解決手段】式（ＩＶ）で示されるキラルなプロリンアミド類化合物を配位子とするイリジウム（III）錯体。（ＸはCl−，p-CH3C6H4SO3−，CH3SO3−，CF3SO3−，NO3−，BF4−，ClO4−，PF6−，SbF6−，B[3,5−di(trifluoromethyl)phenyl]4−又はB(4−fluorophenyl)4−；Ｌはプロリンアミド類化合物；Cp＊は（１，２，３，４，５−η）−ペンタメチル−２，４−シクロペンタジエン−１−イル）【選択図】図１