NOVEL SERPENTINE TRANSMEMBRANE ANTIGENS EXPRESSED IN HUMAN CANCERS AND USES THEREOF

• Main Authors: RAITANO ARTHUR B, AFAR DANIEL E, LEONG KAHAN, MITCHELL STEPHEN CHAPPELL, HUBERT RENE S, SAFFRAN DOUGLAS C
• Format: Patent
• Language: English; Japanese
• Published: 18.05.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a novel family of cell surface serpentine transmembrane antigens.SOLUTION: The invention provides STRAP-1 protein being the prototype member of the Serpentine Transmembrane Antigens of the Prostate (STRAP) family structurally characterized by a molecular topology of six transmembrane domains and intracellular N- and C termini, where STRAP-1 is a protein of 339 amino acids with a specified sequence. The invention also provides an isolated polynucleotide encoding the above protein, a recombinant vector comprising the polynucleotide, and a host cell comprising the expression vector.SELECTED DRAWING: Figure 1A-1 【課題】細胞表面蛇行性膜貫通抗原の新規ファミリーを提供する。【解決手段】前立腺で発現され、特定の配列を有する蛇行性膜貫通抗原（ＳＴＲＡＰ）ファミリーの原型となるメンバーであるＳＴＲＡＰ−１蛋白質であって、構造的には６つの膜貫通ドメインならびに細胞内N-およびＣ末端を有する分子トポロジーを特徴とする３３９アミノ酸の蛋白質、前記タンパク質をコードする単離ポリヌクレオチド、前記ポリヌクレオチドを含む組換えベクターおよび前記発現ベクターを含む宿主細胞。【選択図】図１Ａ−１