LIQUID COMPOSITION AND FREEZE-DRIED PREPARATION

• Main Authors: MATSUDA KENSAKU, YAMAWAKI NORIHIKO, TAGUCHI CHIHO, MURAKAMI TAKUHIRO
• Format: Patent
• Language: English; Japanese
• Published: 30.03.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a preparation which has good storage stability and can maintain the stability of physiologically active peptide for a long period of time.SOLUTION: A liquid composition contains a physiologically active peptide or a pharmaceutically acceptable salt thereof, and a stabilizer comprising at least one of the following compounds A to C: the compound A is arginine, histidine, glutamic acid or a pharmaceutically acceptable salt thereof; the compound B is an aromatic compound having a hydroxyl group or a pharmaceutically acceptable salt thereof; and the compound C is a compound represented by the formula (I) of Ar-(CO-NRR)(I), wherein Ar is a monocyclic or condensed aromatic heterocyclic ring, Rand Rare H or a compound residue, or Rand Rmay be bonded to Ar, and n is an integer of 1 to 3.SELECTED DRAWING: None 【課題】保存安定性が良好であり、生理活性ペプチドの安定性を長期にわたって維持することができる製剤の提供。【解決手段】生理活性ペプチド又はその薬学的に許容され得る塩、及び下記化合物Ａ〜Ｃを１以上含む安定化剤を含有する液体組成物。化合物Ａ：アルギニン、ヒスチジン、グルタミン酸又はこれらの薬学的に許容される塩化合物Ｂ：水酸基を有する芳香族化合物又はその薬学的に許容される塩化合物Ｃ：式（Ｉ）Ａｒ−（ＣＯ−ＮＲ１Ｒ２）ｎ（Ｉ）〔Ａｒは単環又は縮合環の芳香族複素環；Ｒ１及びＲ２はＨ又は化合物残基；或いはＲ１及びＲ２はＡｒと結合していてもよい；ｎは１〜３の整数〕【選択図】なし