NOVEL ELLAGITANNINS AND AGENTS FOR ORAL APPLICATIONS

• Main Authors: NAKANO FUSAKO, SHIRATAKE SAWAKO
• Format: Patent
• Language: English; Japanese
• Published: 16.03.2017
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

PROBLEM TO BE SOLVED: To provide novel compounds, APQ5 mRNA expression promoting agents, APQ3 mRNA expression promoting agents, plaque formation inhibitors, and SPT mRNA expression promoting agents.SOLUTION: The invention provides novel ellagitannins. As the active ingredients, APQ5 mRNA expression promoting agents, APQ3 mRNA expression promoting agents, plaque formation inhibitors and SPT mRNA expression promoting agents contain the novel ellagitannin, 2,3-O-hexahydroxydiphenoyl-4,6-O-sanguisorboyl glucose, rubusuaviin A, brevifolin carboxylic acid, isostrictinin, rubusoside, ellagic acid, or Tencha (Rubus suavissimus) extracts.SELECTED DRAWING: None 【課題】新規化合物、作用効果に優れたＡＰＱ５ｍＲＮＡ発現促進剤、ＡＰＱ３ｍＲＮＡ発現促進剤、プラーク形成抑制剤及びＳＰＴｍＲＮＡ発現促進剤の提供。【解決手段】新規エラジタンニン。また、ＡＰＱ５ｍＲＮＡ発現促進剤、ＡＰＱ３ｍＲＮＡ発現促進剤、プラーク形成抑制剤およびＳＰＴｍＲＮＡ発現促進剤の有効成分として、新規エラジタンニン、２，３−Ｏ−ヘキサヒドロキシジフェノイル−４，６−Ｏ−サングイソルボイルグルコース、ルブスアビインＡ、ブレビフォリンカルボン酸、イソストリクチニン、ルブソサイド、エラグ酸又は甜茶抽出物を含有させる。【選択図】なし