MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII

• Main Authors: SAMPEI ZENJIRO, MUTO ATSUSHI, IMAI CHIFUMI, IGAWA TOMOYUKI, SOEDA TETSUHIRO, KITAZAWA TAKEHISA, KOJIMA TETSURO, NISHIDA YUKIKO, YOSHIHASHI KAZUTAKA, SUZUKI TSUKASA
• Format: Patent
• Language: English; Japanese
• Published: 09.03.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a multi-specific antigen-binding molecule having an alternative function to the function of blood coagulation factor VIII.SOLUTION: The present invention provides a multi-specific antigen-binding molecule with high activity substituting for the function of blood coagulation factor VIII. The molecule is found out among various prepared bispecific antibodies each specifically binding to both the blood coagulation factor IX/activated blood coagulation factor IX and the blood coagulation factor X and having an alternative function to the cofactor function of the blood coagulation factor VIII, i.e., the function of promoting the activation of the blood coagulation factor X by the activated blood coagulation factor IX.SELECTED DRAWING: None 【課題】血液凝固第ＶＩＩＩ因子の機能を代替する機能を有する多重特異性抗原結合分子の提供。【解決手段】血液凝固第IX因子/活性化血液凝固第IX因子及び血液凝固第X因子の双方に特異的に結合し、血液凝固第VIII因子の補因子機能、すなわち活性化血液凝固第IX因子による血液凝固第X因子活性化を促進する機能を代替する機能を有する種々の二重特異性抗体を作製し、これらの抗体の中から、見出した血液凝固第VIII因子の機能を代替する活性の高い多重特異性抗原結合分子。【選択図】なし