SYSTEM AND METHOD FOR DELIVERING THERAPEUTIC AGENT

• Main Authors: HANSON S GIFFORD, DEEM MARK E
• Format: Patent
• Language: English; Japanese
• Published: 23.02.2017
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ELECTROTHERAPY; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MAGNETOTHERAPY; MEDICAL OR VETERINARY SCIENCE; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROSTHESES; RADIATION THERAPY; TREATMENT OR PROTECTION OF EYES OR EARS; ULTRASOUND THERAPY

PROBLEM TO BE SOLVED: To provide a system and a method for delivering a therapeutic agent.SOLUTION: A fragment of a neurotoxin such as an active light chain (LC) of a botulinum toxin (BoNT) such as one of serotype A, B, C, D, E, F, or G botulinum toxin, is applied by transparency of a target cell film, in which the fragment of the neurotoxin is caused to traverse the target cell film and reaches cytoplasm sols of cells in which therapeutic response is generated in a mammal, translocation of a molecule of the botulinum toxin light chain (BoNT-LC) is achieved. The method and device comprise use of a delivery system based on a catheter, a non-invasive delivery system, and a percutaneous delivery system.SELECTED DRAWING: None 【課題】治療薬の送達のためのシステムおよび方法を提供すること【解決手段】血清型Ａ、Ｂ、Ｃ、Ｄ、Ｅ、Ｆ、またはＧボツリヌス毒素の１つなどのボツリヌス毒素（ＢｏＮＴ）の活性軽鎖（ＬＣ）などの神経毒のフラグメントを、標的細胞膜の透過化により適用し、標的細胞膜を横断して哺乳類系において治療応答が作り出される細胞の細胞質ゾルに至る、ボツリヌス毒素軽鎖（ＢｏＮＴ−ＬＣ）分子のトランスロケーションを可能にする、方法および装置を提供する。この方法および装置は、カテーテルに基づく送達システム、非侵襲性送達システム、および経皮的送達システムの使用を含む。【選択図】なし