SUSTAINED RELEASE FORMULATIONS OF LORAZEPAM

PROBLEM TO BE SOLVED: To provide a lorazepam formulation that provides a sustained release profile with a potential for an effective and well tolerated once daily dosing regimen required.SOLUTION: The invention relates to sustained release lorazepam compositions that provide greatly prolonged releas...

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Bibliographic Details
Main Authors MICHAEL VACHON, DOUGLAS A SALTEL
Format Patent
LanguageEnglish
Japanese
Published 26.01.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a lorazepam formulation that provides a sustained release profile with a potential for an effective and well tolerated once daily dosing regimen required.SOLUTION: The invention relates to sustained release lorazepam compositions that provide greatly prolonged release of lorazepam, which are each a pharmaceutical composition comprising (i) lorazepam sustained release beads, and (ii) lorazepam delayed sustained release beads, where the total amount of lorazepam contained in the composition is 0.5 to 10 mg.SELECTED DRAWING: Figure 1 【課題】必要とされている、効果的で十分耐容性のある１日１回の投薬計画を行う可能性のある、徐放性プロファイルを提供するロラゼパム製剤を提供する。【解決手段】非常に長いロラゼパム放出を行う、徐放性ロラゼパム組成物であって、（ｉ）ロラゼパム徐放性ビーズと（ｉｉ）ロラゼパム遅延徐放性ビーズとを含み、前記組成物に含有されるロラゼパムの全量が０．５〜１０ｍｇである医薬組成物に関する。【選択図】図１
Bibliography:Application Number: JP20160216160