HETERO TYPE SINGLE DISPERSION POLYETHYLENE GLYCOL, INTERMEDIATE FOR MANUFACTURING HETERO TYPE SINGLE DISPERSION POLYETHYLENE GLYCOL AND MANUFACTURING METHOD THEREFOR AND HETERO TYPE SINGLE DISPERSION POLYETHYLENE GLYCOL BOUND BODY

• Main Authors: URUGA YUKI, KYO YOSHITETSU, MURAOKA TAKAHIRO, IMAMURA RYUTARO, ADAM MARCIN WAWRO, OTAKE TOMOYUKI, KANEHARA KAZU
• Format: Patent
• Language: English; Japanese
• Published: 19.01.2017
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP

PROBLEM TO BE SOLVED: To provide hetero type single dispersion polyethylene glycol containing hetero type polyethylene glycol having an amino group and a carboxyl group in both terminals respectively and same ethylene glycol chain length as a main component especially at high purity.SOLUTION: There is provided hetero type single dispersion polyethylene glycol containing a compound represented by the following formula (1):NH-(CHCHO)-CHCHCOOH (1), where a represents an integer of 6 to 40, and having (A) a chromatogram detected by a differential refractive index meter when separated by using a reversed phase chromatography, (B) a chromatogram detected by the differential refractive index meter when separated by using a cation exchange chromatography and (C) a chromatogram detected by the differential refractive index meter when hetero type single dispersion polyethylene glycol containing the compound represented by the formula (1) is derivatized and separated by using an anion exchange chromatography, which satisfy specific relational expressions.SELECTED DRAWING: None 【課題】 両末端にそれぞれアミノ基とカルボキシル基とを有し、エチレングリコール鎖長が互いに同じであるヘテロ型ポリエチレングリコールを、主成分として特に高純度で含有するヘテロ型単分散ポリエチレングリコールを提供すること。【解決手段】 下記式（１）：ＮＨ２−（ＣＨ２ＣＨ２Ｏ）ａ−ＣＨ２ＣＨ２ＣＯＯＨ ・・・（１）［式（１）中、ａは６〜４０の整数を示す。］で表される化合物を含有するヘテロ型単分散ポリエチレングリコールにおいて、（Ａ）逆相クロマトグラフィーを用いて分離したときの示差屈折率計で検出されるクロマトグラム、（Ｂ）陽イオン交換クロマトグラフィーを用いて分離したときの示差屈折率計で検出されるクロマトグラム、及び、（Ｃ）前記式（１）で表される化合物を含有するヘテロ型単分散ポリエチレングリコールを誘導体化して陰イオン交換クロマトグラフィーを用いて分離したときの示差屈折率計で検出されるクロマトグラムが、いずれも特定の関係式を満たすことを特徴とするヘテロ型単分散ポリエチレングリコール。【選択図】 なし