PATHOLOGICAL BIOMARKERS FOR KIDNEY DISEASES

PROBLEM TO BE SOLVED: To provide an analysis method that enables diagnosis of early and mild renal disorder.SOLUTION: An analysis method involves calculating a pathological index value of renal disorder based on amounts of D- and/or L-amino acids in stool or intestinal contents. Comparison of the pa...

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Main Authors SAKAI NOBUHIKO, MIYOSHI YURIKA, WADA TAKASHI, IWATA YASUNORI, HAMASE KENJI, MITA MASASHI, NAKANE MAIKO, FURUICHI KENGO, NAKADE YUSUKE, HARA AKINORI
Format Patent
LanguageEnglish
Japanese
Published 05.01.2017
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:PROBLEM TO BE SOLVED: To provide an analysis method that enables diagnosis of early and mild renal disorder.SOLUTION: An analysis method involves calculating a pathological index value of renal disorder based on amounts of D- and/or L-amino acids in stool or intestinal contents. Comparison of the pathological index value with a threshold value determined from pathological index values of a group of renal failure patients and a group of healthy individuals enables diagnosis of patients with mild renal disorder.SELECTED DRAWING: Figure 13 【課題】本発明は、早期又は軽度の腎障害の診断を可能にする分析方法の開発を課題とする。【解決手段】糞便又は腸内容物からＤ体及び／又はＬ体のアミノ酸量に基づき腎障害の病態指標値を算出することに基づく。この病態指標値を、腎不全患者群及び健常者群の病態指標値から決定された閾値と比較することにより、軽度の腎障害患者群の診断が可能になる。【選択図】図１３
Bibliography:Application Number: JP20160116722