LIGNAN COMPOUND

• Main Authors: YASUMA CHIEKO, SUZUKI YOSHITO, YANA AKIHIDE
• Format: Patent
• Language: English; Japanese
• Published: 05.01.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

PROBLEM TO BE SOLVED: To provide a compound having activity to inhibit growth of cancer stem cell, a manufacturing method of the compound and a pharmaceutical composition and a food composition containing the compound.SOLUTION: There is provided a lignan compound obtained by a manufacturing method including (A) a process of extracting Chinese gutta percha with water or water/alcohol mixed solvent to obtain an extract, (B) a process of extracting the extract with alcohol to obtain a water phase and an alcohol phase and (C) a process of separation purifying the water phase by normal phase chromatography and then reverse phase chromatography.SELECTED DRAWING: None 【課題】ガン幹細胞の生育を阻害する活性を有する化合物、該化合物の製造方法、ならびに該化合物含む医薬組成物および食品組成物を提供する。【解決手段】（Ａ）杜仲葉を水または水／アルコール混合溶媒で抽出して抽出液を得る工程、（Ｂ）当該抽出液をアルコールで抽出して、水相とアルコール相を得る工程、ならびに（Ｃ）前記水相を、順相クロマトグラフィー、次いで逆相クロマトグラフィーにより分離精製する工程、を含む、製造方法により得られるリグナン系化合物。【選択図】なし