BONE DEFECT FILLING MATERIAL, AND METHOD FOR PRODUCING THE SAME

• Main Authors: KASUGA TOSHIHIRO, MAKITA MASASHI
• Format: Patent
• Language: English; Japanese
• Published: 05.01.2017
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

PROBLEM TO BE SOLVED: To provide a bone defect filling material that initiates a bone rebuilding action as quickly as possible following implantation and that afterward remains in the defect and continues acting to promote bone formation activity until sufficient bone formation has been achieved for the rebuilding of the defect, in which rebuilding a bone with the defect by activation of the innate self-regeneration ability of the bone requires a considerably long period of time.SOLUTION: The present invention provides a cotton-like bone defect filling material comprising biodegradable fibers produced by electrospinning, in which the biodegradable fibers contain 40-60 wt% of calcium phosphate particles and 10 wt% or more of silicon-eluting calcium carbonate particles, with the balance containing 30 wt% or more of poly L-lactic acid resin, and the amount of the poly L-lactic acid resin that is non-crystalline is 75-98%.SELECTED DRAWING: Figure 15 【課題】欠損した骨を骨本来の自己再生能力を活かして再建するのには相当の長期間を要する。本発明は、埋入された後骨再建作用をできるだけ早く開始させ、さらにその後欠損部を再建するのに十分な骨の形成が得られるまで欠損部に残って骨形成活動を促進する作用を継続する骨欠損部充填材料を提供することを目的とする。【解決手段】本発明は、エレクトロスピニングで製造された生分解性繊維からなる綿状の骨欠損部充填材料であり、前記生分解性繊維は、リン酸カルシウム粒子を４０〜６０重量％、ケイ素溶出型炭酸カルシウム粒子を１０重量％以上、残部にポリＬ乳酸樹脂を３０重量％以上含んでおり、前記ポリＬ乳酸樹脂は非晶質相量が７５〜９８％である、骨欠損部充填材料を提供する。【選択図】図１５