PROCESS FOR PREPARING DIHYDRO-PYRROLE DERIVATIVE

• Main Authors: PETER RENOLD, JEROME YVES CASSAYRE, NICHOLAS PHILLIP MULHOLLAND, EDOUARD GODINEAU, MYRIEM EL QACEMI, HELMARS SMITS, THOMAS PITTERNA
• Format: Patent
• Language: English; Japanese
• Published: 15.12.2016
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

PROBLEM TO BE SOLVED: To provide a substituted dihydro-pyrrole derivative that has a pesticidal activity, and to provide a stereoselective synthesis process.SOLUTION: Provided is a substituted dihydro-pyrrole derivative prepared by deprotecting, decarboxylating and cyclizing a compound represented by formula (XXIII) according to a stepwise one-pot procedure without intermediate isolation. (P is phenyl, naphthyl, heteroaryl and the like; Ris chlorodifluoromethyl or trifluoromethyl; Ris substituted/unsubstituted aryl or substituted/unsubstituted heteroaryl; Y is substituted/unsubstituted aryl; W is H or substituted/unsubstituted aryl; and Z is substituted/unsubstituted alkyl or substituted/unsubstituted arylalkylene.)SELECTED DRAWING: None 【課題】有害生物防除活性を有する置換ジヒドロ−ピロール誘導体、及び立体選択的合成法の提供。【解決手段】中間体を単離しない段階的なワンポット手法に従って、式（ＸＸＩＩＩ）で表される化合物を脱保護、脱カルボキシル化及び環化することにより調製される、置換ジヒドロ−ピロール誘導体。（Ｐは、フェニル、ナフチル、ヘテロアリール等；Ｒ1はクロロジフルオロメチル又はトリフルオロメチル；Ｒ2は置換／非置換のアリール又は置換／非置換のヘテロアリール；Ｙは置換／非置換のアリール；ＷはＨ又は置換／非置換のアリール；Ｚは置換／非置換のアルキル又は置換／非置換のアリールアルキレン）【選択図】なし