LINKER AND CARRIER FOR NUCLEIC ACID SOLID-PHASE SYNTHESIS

• Main Authors: MORI KENJIRO, MAEDA ERI, ITO TAKAHIKO, SAITO SHOICHIRO, HORIE SHOHEI, NAGAO RYUHEI
• Format: Patent
• Language: English; Japanese
• Published: 08.12.2016
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a universal linker that can suppress the occurrence of by-products and can synthesize DNA and RNA with improved efficiency and improved purity, a carrier for nucleic acid solid-phase synthesis (universal support) carrying the linker, and a method for producing a nucleic acid using the carrier.SOLUTION: The present invention provides a carrier for nucleic acid solid-phase synthesis represented by the following formula (III).SELECTED DRAWING: None 【課題】本発明は、副生成物の発生を抑えることができ、より効率的に高い純度でＤＮＡやＲＮＡを合成することができるユニバーサルリンカー、該リンカーを担持した核酸固相合成用担体（ユニバーサルサポート）、及び該担体を用いた核酸の製造方法を提供する。【解決手段】本発明は、下記式（ＩＩＩ）で示される核酸固相合成用担体を提供する。【選択図】なし