SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS

PROBLEM TO BE SOLVED: To provide compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8.SOLUTION: The present invention provides a compound of formula I (where each symbol is as defined in the specifications) or pharmaceutically acceptable salt t...

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Main Authors YANG HONG WOON, ROBERT D GRONEBERG, ZACHARY JONES, JAMES JEFFLY HOWBERT, LYSSIKATOS JOSEPH P, ROBERT HERSHBERG, BURGESS LAURENCE E, GEORGE A DOHERTY, CHARLES TODD EARY
Format Patent
LanguageEnglish
Japanese
Published 01.12.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8.SOLUTION: The present invention provides a compound of formula I (where each symbol is as defined in the specifications) or pharmaceutically acceptable salt thereof.SELECTED DRAWING: Figure 2 【課題】Ｔｏｌｌ様受容体ＴＬＲ７および／またはＴＬＲ８を介してのシグナル伝達を調節するために有用な組成物および方法を提供する。【解決手段】式Ｉ（式中、各記号は明細書中の定義と同意義である。）を有する化合物または薬学的に許容されるその塩。【選択図】図２
Bibliography:Application Number: JP20160152504