ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)

PROBLEM TO BE SOLVED: To provide antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (PCSK9) and their use as pharmaceuticals.SOLUTION: An isolated monoclonal antibody binds to at least one specific residue of a specific sequence when binding to PCSK9, and block...

Full description

Saved in:
Bibliographic Details
Main Authors SHAN BEI, SHEN WENYAN, JACKSON SIMON MARK, DEREK EVAN PIPER, NIGEL PELHAM CLINTON WALKER, RANDAL ROBERT KET, CAO QIONG, CHAN JOYCE CHI YEE, CHADWICK TERENCE KING, MEHLIN CHRISTOPHER, TERESA ARAZAS CARABEO
Format Patent
LanguageEnglish
Japanese
Published 20.10.2016
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:PROBLEM TO BE SOLVED: To provide antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (PCSK9) and their use as pharmaceuticals.SOLUTION: An isolated monoclonal antibody binds to at least one specific residue of a specific sequence when binding to PCSK9, and blocks the binding of PCSK9 to LDLR.SELECTED DRAWING: Figure 26 【課題】プロタンパク質コンベルターゼスブチリシンケクシン９型（ＰＣＳＫ９）と相互作用する抗原結合タンパク質並びにその医薬品としての使用。【解決手段】ＰＣＳＫ９に結合するとき、特定の配列の特定の残基の少なくとも一つに結合し、ＰＣＳＫ９のＬＤＬＲへの結合を遮断する、単離されたモノクロナール抗体。【選択図】図２６
Bibliography:Application Number: JP20160053430