COMPOUNDS FOR THE TREATMENT OF HIV

• Main Authors: CANNIZZARO CARINA E, SCOTT D SCHROEDER, JOHN O LINK, JENNIFER R ZHANG, RANDALL L HALCOMB, YUN-FENG ERIC HU, CHOU CHIEN-HUNG, LIU QI, TSE WINSTON C, STEVEN S BONDY
• Format: Patent
• Language: English; Japanese
• Published: 29.09.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a compounds for the treatment of HIV.SOLUTION: The invention provides compounds of formula (I) or a salt thereof, where A is a 6-membered heteroaryl comprising one or two nitrogens; B is absent or B is -O- and the nitrogen to which the -O- group is attached is N+; W is -CR3aR3b-, -O-, -NR4-, -OCR3aR3b- or absent; R1 is aryl, heteroaryl or heterocycle; R2 is a 6-membered aryl, 5-membered heteroaryl or 6-membered heteroaryl; each of R3a and R3b is independently selected from H, halogen, (C1-C6)alkyl, (C3-C7)carbocycle, and the like; R4 is selected from H, (C1-C6)alkyl, (C3-C6)carbocycle, and the like.SELECTED DRAWING: None 【課題】ＨＩＶを処置するための化合物の提供。【解決手段】式（Ｉ）の化合物、またはその塩。式中、Ａは１個または２個の窒素を含む６員ヘテロアリール；Ｂは存在しないか、または−Ｏ−であり、この−Ｏ−基が結合している窒素はＮ＋であり；Ｗは、−ＣＲ３ａＲ３ｂ−、−Ｏ−、−ＮＲ４−、もしくは−ＯＣＲ３ａＲ３ｂ−であるか、または存在せず；Ｒ１は、アリール、ヘテロアリールまたは複素環；Ｒ２は、６員アリール、５員ヘテロアリールまたは６員ヘテロアリール；各Ｒ３ａおよび各Ｒ３ｂは独立して、Ｈ、ハロゲン、（Ｃ１〜Ｃ６）アルキル、（Ｃ３〜Ｃ７）炭素環等；Ｒ４は、Ｈ、（Ｃ１〜Ｃ６）アルキル、（Ｃ３〜Ｃ６）炭素環等である。【選択図】なし