NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS

• Main Authors: BAHWINDER SINGH BHATTI, MATT S MELVIN, JASON SPEAKE, DANIEL YOHANNES, AKIREDDY SRINIVASA RAO, XIAO YUNDE, RONALD JOSEPH HEEMSTRA
• Format: Patent
• Language: English; Japanese
• Published: 29.09.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, and methods for their use as pharmaceutical compositions.SOLUTION: The present invention provides a compound represented by formula 1 (Rand Rindependently represent H, alkyl, or arylalkyl or form a substituted/unsubstituted 3-8 membered ring together with nitrogen; R-Rindependently represent H, alkyl, or alkoxy; Land Lare a linker comprising an alkylene group and the like).SELECTED DRAWING: None 【課題】非競合的アンタゴニストとしてニコチン性受容体を調節する化合物、その合成方法及び医薬組成物としての使用方法の提供。【解決手段】式1で表される化合物。（Ｒ1及びＲ2は夫々独立にＨ、アルキル、アリールアルキル又は窒素と一緒に置換／非置換の3〜8員環を形成；Ｒ3−Ｒ7は各々独立にＨ、アルキル、アルコキシ；Ｌ1及びＬ2はアルキレン基等からなるリンカー）【選択図】なし