COMPOSITIONS OF ASYMMETRIC INTERFERING RNA AND USES THEREOF

• Main Authors: SUN XIANGAO, HARRY ROGOFF, LI YOUZHI, LI CHIANG JIA
• Format: Patent
• Language: English; Japanese
• Published: 29.09.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide compositions of asymmetric interfering RNA and uses thereof.SOLUTION: The invention provides asymmetry double-stranded RNA molecules capable of sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed of the first and second strands and two ends independently selected from a group consisting of 5'-overhang, 3'-overhang and a blunt end. The RNA molecule of the invention can be used as a research tool and/or therapeutic agent.SELECTED DRAWING: Figure 1 【課題】非対称性干渉ＲＮＡの組成物およびその使用の提供。【解決手段】本発明は、配列特異的な遺伝子サインレンシングを実施することが可能な、非対称性二重鎖ＲＮＡ分子を提供する。該ＲＮＡ分子は、第１鎖および第２鎖を含む。該第１鎖は該第２鎖よりも長い。該ＲＮＡ分子は、該第１鎖および該第２鎖により形成される二本鎖領域と、５'突出、３'突出、および平滑末端からなる群から独立に選択される２つの末端とを含む。本発明のＲＮＡ分子は、研究用ツールおよび／または治療薬として用いることができる。【選択図】図１