NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE COMPOUNDS AND 3,5-DISUBSTITUTED-3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS PROTEIN KINASE MODULATORS

• Main Authors: GOVINDARAJULU BABU, SWAROOP K V S VAKKALANKA, MEYYAPPAN MUTHUPPALANIAPPAN, SRIKANT VISWANADHA
• Format: Patent
• Language: English; Japanese
• Published: 08.09.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide novel compounds as protein kinase modulators, and pharmaceutical compositions containing them.SOLUTION: The invention provides imidazo[4,5-B]pyridine compounds and triazolo[4,5-B]pyridine compounds represented by the following formula, and pharmaceutical compositions containing them, effective in treatment of disease associated with protein kinase modulation such as immune disorder, cardiovascular disease and inflammatory disease. [In the formula, Rand Reach represent H or the like, X represents N or the like, Cyand Cyeach represent a heterocyclic group, and Lrepresents an alkyl group or the like.]SELECTED DRAWING: None 【課題】プロテインキナーゼ調節物質としての新規な化合物、及びそれらを含む医薬組成物の提供。【解決手段】下記式であらわされる、イミダゾ[4,5-B]ピリジン化合物、及びトリアゾロ[4,5-B]ピリジン化合物、及びこれらを含む、免疫障害、心血管疾患及び炎症性疾患等のプロテインキナーゼ調節に関わる疾患の治療に有効な医薬組成物。[式中、Ｒ１及びＲ２はＨ等を、ＸはＮ等を、Ｃｙ１及びＣｙ２は複素環式基、及びＬ２はアルキル基等を、それぞれ表す。]【選択図】なし