PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR TREATMENT OF CANCER

• Main Authors: HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, JOEL MCINTOSH, SUN DAQING, JIAO XIANYUN, DAVID JOHN KOPECKY, FU ZICE, JONATHAN DANTE LOW, WANG XIAODONG, JASON DUQUETTE, STEVEN HOWARD OLSON, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, JIASHENG FU, MCGEE LAWRENCE, DUSTIN MCMINN, HILARY PLAKE BECK, JULIO CESAR MEDINA, JULIE ANNE HEATH, MICHAEL WILLIAM GRIBBLE JR, KAYSER FRANK, MA ZHIHUA, REW YOSUP, GONZALES LOPEZ DE TURISO FELIX, LAI SUJEN, ROVETO PHILIP MARLEY, CHEN XIAOQI, JEFFREY DEIGNAN, JOHN EKSTEROWICZ, JOHNSON MICHAEL, ANA GONZALEZ BUENROSTRO, LI ZHIHONG, CONNORS RICHARD VICTOR, JEFFREY THOMAS MIHALIC, YU MING, BARTBERGER MICHAEL DAVID, DARIN JAMES GUSTIN, WANG YINGCAI
• Format: Patent
• Language: English; Japanese
• Published: 18.08.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide compounds that inhibit interaction between p53 and MDM2 and activate p53 downstream effector genes thereby being MDM2 inhibitors useful as therapeutic agents for treatment of cancer.SOLUTION: A pharmaceutical composition contains a compound represented by the formula in the figure.SELECTED DRAWING: None 【課題】ｐ５３とＭＤＭ２間の相互作用を阻外し、ｐ５３下流のエフェクター遺伝子活性化することによる癌の治療のための治療薬として有用なＭＤＭ２阻害剤である化合物の提供。【解決手段】下記式で例示される化合物を含有する医薬組成物。【選択図】なし