METHOD FOR TREATING LIVER DISORDER WITH RECEPTOR ASSOCIATED PROTEIN (RAP) PEPTIDE-FUCOSIDASE INHIBITOR CONJUGATE

• Main Author: ZANKEL TODD C
• Format: Patent
• Language: English; Japanese
• Published: 12.08.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a composition and method for treating liver disorders, such as hepatocellular carcinoma.SOLUTION: The present invention generally relates to a method and composition for the treatment of liver disorders and hepatic tumor such as hepatocellular carcinoma with peptides of a receptor associated protein (RAP) molecule conjugated to a fucosidase inhibitor. In one embodiment, a peptide conjugate containing a receptor associated protein (RAP) peptide bound to a fucosidase inhibitor is provided, the RAP peptide comprising a polypeptide sequence at least 80% homologous to amino acid sequences of 210-319 from N-terminus amino acid sequence of a human RAP peptide.SELECTED DRAWING: None 【課題】肝細胞癌等の肝障害を処置するための組成物および方法を提供すること。【解決手段】本発明は、概して、フコシダーゼ阻害薬に複合化した受容体関連タンパク質（ＲＡＰ）分子のペプチドによる、肝細胞癌等の肝障害および肝腫瘍の処置のための方法および組成物に関する。一実施形態において、フコシダーゼ阻害剤に結合した受容体関連タンパク質（ＲＡＰ）ペプチドを含むペプチド複合体が提供され、このＲＡＰペプチドは、ヒトＲＡＰペプチドのＮ末端アミノ酸から２１０〜３１９のアミノ酸配列と少なくとも８０％相同性のポリペプチド配列を含む。【選択図】なし