CHEMOKINE RECEPTOR ANTAGONIST AND METHOD OF USE THEREOF

• Main Authors: LULY JAY R, NAKASATO YOSHISUKE, OSHIMA ETSUO, MATTIA KAREN M, GHOSH SHOMIR, ELDER AMY M, HARRIMAN GERALDINE C B, CARSON KENNETH G
• Format: Patent
• Language: English; Japanese
• Published: 04.08.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a low molecular weight compound being an antagonist of chemokine receptor function.SOLUTION: The method comprises administering to a subject an effective amount of a compound represented by formulas (I) and (II) or physiologically acceptable salt thereof. (n is an integer from 1 to 4; M is >NR, >CRR, -O-CRR-O-, or -CH-CRR-O-; qis an integer from 0 to 3; qis 0 or 1; Ris H, OH, N, halogen, a substituted/unsubstituted aliphatic group, -SH, CN or the like; and Ris OH, halogen, substituted/unsubstituted alkyl, substituted amino, aliphatic group, aromatic group or the like.)SELECTED DRAWING: None 【課題】ケモカイン受容体機能のアンタゴニストである低分子化合物の提供。【解決手段】有効量の式（Ｉ）及び（ＩＩ）で表される化合物およびその生理学上許容される塩を対象に投与する方法。（ｎは１〜４の整数；＞ＮＲ２、＞ＣＲ１Ｒ２、−Ｏ−ＣＲ１Ｒ２−Ｏ−又は−ＣＨ２−ＣＲ１Ｒ２−Ｏ−；ｑ１は０〜３の整数；ｑ２は０又は１；Ｒ１はＨ、ＯＨ、Ｎ３、ハロゲン、置換／非置換脂肪族基、−ＳＨ、ＣＮ等；Ｒ２はＯＨ、ハロゲン、置換／非置換のアルキル、置換アミノ、脂肪族基、芳香族基等）【選択図】なし