N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS

• Main Authors: KALISH VINCENT JACOB, FROST LISA MARIE, TOSCANO JOHN P, BROOKFIELD FREDERICK ARTHUR, COHEN ANDREW D, COURTNEY STEPHEN MARTIN
• Format: Patent
• Language: English; Japanese
• Published: 04.08.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide compounds that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or abnormalities that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury.SOLUTION: The invention relates to N-hydroxylsulfonamide derivatives represented by the formula (I), where the phenyl ring may be a heterocycle such as a naphthalene ring or thiophene.SELECTED DRAWING: None 【課題】生理的条件下でニトロキシル（ＨＮＯ）を供与し、心不全および虚血／再灌流傷害を含む、ニトロキシル療法に応答する疾患または異常の、開始および／または進行を処置および／または予防するのに有用である化合物の提供。【解決手段】式（Ｉ）に代表されるＮ−ヒドロキシルスルホンアミド誘導体。フェニル環はナフタレン環、チオフェンなどのヘテロ環であってもよい。【選択図】なし