BUPRENORPHINE ANALOGS

PROBLEM TO BE SOLVED: To provide buprenorphine analogs having activity as opioid receptor agonists and/or antagonists.SOLUTION: This invention relates to compositions represented by formula (I). The compounds of the Invention are useful for treating pain, constipation, and other conditions modulated...

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Bibliographic Details
Main Authors KYLE DONALD J, TAFESSE LAYKEA
Format Patent
LanguageEnglish
Japanese
Published 02.06.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide buprenorphine analogs having activity as opioid receptor agonists and/or antagonists.SOLUTION: This invention relates to compositions represented by formula (I). The compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors. This invention further relates to a using method for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.SELECTED DRAWING: Figure 1 【課題】オピオイド受容体アゴニスト及び／又はアンタゴニストとして活性を有するブプレノルフィン類似体の提供。【解決手段】式（Ｉ）で表される化合物。前記化合物は疼痛、便秘並びにオピオイド及びＯＲＬ−１受容体の活性により調節される他の状態を治療するために使用する方法。【選択図】図１
Bibliography:Application Number: JP20150226945