HYDROXYL, KETO, AND GLUCURONIDE DERIVATIVES OF 3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE

• Main Authors: LEE MAY, FRANK M NEDZA, SHEPARD STACEY, ADAM SHILLING, LAURINE G GALYA, RODGERS JAMES D, ARVANITIS ARGYRIOS G
• Format: Patent
• Language: English; Japanese
• Published: 21.04.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide new or improved agents which inhibit kinases such as Janus kinases for developing new and more effective pharmaceuticals to treat cancer and other diseases.SOLUTION: The present invention provides hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile.SELECTED DRAWING: None 【課題】癌及び他の疾患を治療する、新しい、より有効な医薬品を開発するために、ヤヌスキナーゼ等のキナーゼを阻害する新しい又は改善された薬剤の提供。【解決手段】本発明は、３−（４−（７Ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）−１Ｈ−ピラゾール−１−イル）−３−シクロペンチルプロパンニトリルのヒドロキシル、ケト及びグルクロニド誘導体を提供する。【選択図】なし