PULMONARY HYPERTENSION THERAPEUTIC AGENT AND SCREENING METHOD FOR THE SAME

• Main Authors: KATAOKA TAKAHIRO, NAKAOKA YOSHIKAZU
• Format: Patent
• Language: English; Japanese
• Published: 21.04.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a novel medicament for the prevention and/or treatment of pulmonary hypertension targeting a molecule involved in the formation of pathological conditions of pulmonary artery pulmonary hypertension by finding out the molecules; and to provide a screening method for pulmonary hypertension therapeutic agent targeting the molecule.SOLUTION: The invention provides a medicament for the prevention and/or treatment of pulmonary hypertension containing as an active ingredient, an agent inhibiting a signaling from IL-21, and a screening method for a pulmonary hypertension therapeutic agent using IL-21 and an IL-21 receptor.SELECTED DRAWING: None 【課題】肺動脈性肺高血圧症の病態形成に関与する分子を見出し、当該分子を標的とする新規な肺高血圧症の予防および／または治療用医薬を提供すること、および、当該分子を標的とする肺高血圧症治療薬のスクリーニング方法を提供すること。【解決手段】ＩＬ−２１からのシグナル伝達を阻害する物質を有効成分とする肺高血圧症の予防および／または治療用医薬、および、ＩＬ−２１およびＩＬ−２１受容体を用いる肺高血圧症治療薬のスクリーニング方法。【選択図】なし