PHOSPHORYLCHOLINE-BASED AMPHIPHILIC SILICONES FOR MEDICAL APPLICATIONS

• Main Authors: JAMES PARAKKA, ANANTH V IYER, WARD ROBERT, WANG ANFENG, TIAN YUAN, JIANG XUWEI
• Format: Patent
• Language: English; Japanese
• Published: 14.04.2016
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; CONTACT LENSES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; OPTICS; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PHYSICS; PROSTHESES; SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURESAS SPECTACLES; THEIR PREPARATION OR CHEMICAL WORKING-UP; TREATMENT OR PROTECTION OF EYES OR EARS

PROBLEM TO BE SOLVED: To provide amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as active functional components in medical device ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.SOLUTION: The invention provides polymerizable or non-polymerizable silicone compounds which comprise a silicone moiety having a weight average molecular weight of 1000 to 1500000 Daltons and include zwitterionic phosphorylcholine groups such as compounds represented by formula (I). The invention also provides polymers derived from the compounds, and medical devices using the polymers.SELECTED DRAWING: None 【課題】医療用具眼用レンズ、眼用レンズケア溶液、液体絆創膏、創傷ドレッシング並びに潤滑性及び抗血栓性コーティングの有効機能成分として、局所用途と内部用途の両方に使用される両親媒性バイオミメティックホスホリルコリン含有シリコーン化合物の提供。【解決手段】重量平均分子量１０００〜１５０００００ダルトンのシリコーン部分を含み、式（Ｉ）で表される化合物等の、双性イオン性ホスホリルコリン基を含む、重合性又は非重合性シリコーン化合物、前記化合物を由来のポリマー、前記ポリマーを使用した医療用具。【選択図】なし