SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS

• Main Authors: MARESKA DAVID A, RAST BRYSON, APRIL L KENNEDY, JAMES P RIZZI, ERIK JAMES HICKEN, GEORGE T TOPALOV, ZHAO QIAN, BRAD NEWHOUSE, MARTHA E RODRIGUEZ, ROBERT KIRK DELISLE, MUNSON MARK C, FREDRIK P MARMSATER, MARK LAURENCE BOYS
• Format: Patent
• Language: English; Japanese
• Published: 24.03.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide compounds which are inhibitors of type III receptor tyrosine kinases such as PDGFR and/or cFMS, which is macrophage colony-stimulating factor-1 receptor, and/or cKIT, expressed on surfaces of early stem cells, mast cells, myeloid cells, mesenchymal cells, and smooth muscles cells for treatment of diseases and disorders such as bone-related diseases, cancer, autoimmune diseases, inflammatory diseases, cardiovascular diseases, fibrosis, pain and burns in mammals.SOLUTION: The invention provides compounds represented by formula I and pharmaceutically acceptable salts thereof.SELECTED DRAWING: None 【課題】哺乳動物における骨関連疾患、癌、自己免疫疾患、炎症性疾患、心血管疾患、線維症、疼痛、及び熱傷の疾患又は障害を治療するための初期幹細胞、マスト細胞、骨髄系細胞、間葉系細胞、及び平滑筋細胞の表面に発現するＰＤＧＦＲ及び／又はマクロファージコロニー刺激因子−１受容体であるｃＦＭＳ及び／又はｃＫＩＴ等のＩＩＩ型受容体チロシンキナーゼの阻害剤である化合物の提供。【解決手段】式Ｉで示される化合物及びその薬剤的に許容可能な塩。【選択図】なし