SYNTHESIS OF PURINE NUCLEOSIDES

• Main Authors: CHANG WONSUK, CHUN BYOUNG-KWON, RACHAKONDA SUGUNA, ZHANG HAI-REN, PAMULAPATI GANAPATI REDDY, NAGARATHNAM DHANAPALAN, DU JINFA, ROSS BRUCE S, SOFIA MICHAEL JOSEPH
• Format: Patent
• Language: English; Japanese
• Published: 17.12.2015
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

PROBLEM TO BE SOLVED: To provide compounds useful for treating conditions caused by viral factors.SOLUTION: The present invention provides compounds represented by formula (I) or formula (II) or salts thereof, and methods of synthesizing the same. (R1 is phenyl group or the like; R2 is H or the like; R3a and R3b are each independently H, a C1-10 alkyl group, or the like; R4 is H, a C1-10 alkyl group, a C3-10 cycloalkyl group, or the like; R5 is H or the like; R6 is H, CH3, or the like; R7 is H, an n-alkyl group, a cycloalkyl group, or the like; R8 is O (lower alkyl), O (lower cycloalkyl), or the like; and R9 is an NH2 group or the like.) 【課題】ウイルス性因子によって引き起こされる状態を治療するのに有用な化合物の提供。【解決手段】式（Ｉ）又は式（ＩＩ）で表される化合物若しくはその塩、及びその合成方法。（Ｒ１はフェニル基等；Ｒ２はＨ等；Ｒ３ａ及びＲ３ｂは各々独立に、Ｈ、Ｃ１−１０アルキル基等；Ｒ４は、Ｈ、Ｃ１−１０アルキル基、Ｃ３−１０シクロアルキル基等；Ｒ５はＨ等；Ｒ６はＨ、ＣＨ３等；Ｒ７はＨ、ｎアルキル基、シクロアルキル基等；Ｒ８はＯ（低級アルキル）、Ｏ（低級シクロアルキル）等；Ｒ９はＮＨ２基等）【選択図】なし