MEDICINE EVALUATION SYSTEM, MEDICINE EVALUATION METHOD, MEDICINE EVALUATION PROGRAM, AND RECORDING MEDIUM

• Main Authors: YAMANAKA TAKESHI, OBA HIROYUKI
• Format: Patent
• Language: English; Japanese
• Published: 07.12.2015
• Subjects: MEASUREMENT OF NUCLEAR OR X-RADIATION; MEASURING; PHYSICS; TESTING

PROBLEM TO BE SOLVED: To provide a medicine evaluation system which is capable of unambiguously determining a control target value regarding an administration speed of a radioactive medicine and capable of sufficiently securing the time for performing the evaluation of the radioactive medicine, and to provide a medicine evaluation method, a medicine evaluation program and a recording medium.SOLUTION: In a medicine evaluation system 1, a characteristic parameter of a radioactive medicine is calculated based on a ratio of the radioactivity quantity per unit time of the radioactive medicine administered to a reference inspection object Sr to a TAC equilibrium time radioactive concentration of a specified region measured by the PET device 11 when the radioactive medicine is administered to the reference inspection object Sr at a constant speed. Further, a control target value of the radioactive concentration of the specified region when the radioactive medicine is administered to an inspection object S is calculated based on a product of the inverse number of the characteristic parameter and the radioactive concentration and the initial administration speed of the radioactive medicine. The administration speed of the radioactive medicine is controlled in a feedback manner based on the control target value and a comparative control parameter until the TAC of the specified region reaches an equilibrium. 【課題】放射性薬物の投与速度に関する制御目標値を一義的に決定できると共に、放射性薬物の評価を行うための時間を十分に確保できる薬物評価システム、薬物評価方法、薬物評価プログラム及び記録媒体を提供する。【解決手段】薬物評価システム１では、基準被検体Ｓｒに放射性薬物を一定速度で投与したときにＰＥＴ装置１１で計測された特定部位のＴＡＣ平衡時放射能濃度と、基準被検体Ｓｒに投与された放射性薬物の単位時間当たりの放射能量との比に基づいて、放射性薬物の特性パラメータを算出する。また、特性パラメータの逆数と、放射性薬物の放射能濃度及び初期投与速度との積に基づいて、被検体Ｓに放射性薬物を投与したときの特定部位の放射能濃度の制御目標値を算出し、特定部位のＴＡＣが平衡に至るまで、当該制御目標値や比例制御パラメータに基づいて放射性薬物の投与速度をフィードバック制御する。【選択図】図１