NOVEL IMMUNOGENIC COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF MENINGOCOCCAL DISEASE

• Main Authors: FLETCHER LEAH D, BERNFIELD LIESEL A, ZLOTNICK GARY W, FARLEY JOHN, ZAGURSKY ROBERT J, METCALF BENJAMIN J
• Format: Patent
• Language: English; Japanese
• Published: 03.12.2015
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide compositions that (1) elicit bactericidal antibodies against multiple neisserial strains, such as strains of Neisseria meningococcus, N. gonococcus and/or N. lactamica; (2) react with the cell surface of multiple strains; (3) confer passive protection against a live challenge; (4) prevent colonization, as well as use methods and production methods of the compositions.SOLUTION: The cross-reactive immunogenic composition comprises: (a) at least a protein encoded by the open reading frame ORF2086 of neisserial strains; or (b) at least an immunogenic portion of the protein in (a); or (c) at least a biological equivalent of the protein in (a) or the immunogenic portion of (b). 【課題】（１）多数のナイセリア菌株、例えば髄膜炎菌、淋菌、及び／又はＮｅｉｓｓｅｒｉａ ｌａｃｔａｍｉｃａに対して殺菌性抗体を産生する；（２）多数の菌株の表面と反応する；（３）実際の攻撃に対して受動的な防護を与える；（４）コロニー化を防ぐ組成物、並びに該組成物の使用法及び該組成物の製造法の提供。【解決手段】以下を含む、交差反応性免疫原性組成物：（ａ）ナイセリア種のオープンリーディングフレームＯＲＦ２０８６によりコードされる少なくとも１つのタンパク質；又は（ｂ）（ａ）に記載の少なくとも１つのタンパク質の少なくとも１つの免疫原性部分；又は（ｃ）（ａ）に記載の少なくとも１つのタンパク質又は（ｂ）に記載の免疫原性部分の、少なくとも１つの生物学的均等物。【選択図】なし