AMORPHOUS AND CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE

• Main Authors: SIEGEL CRAIG, CHENG SENG, LIU HARLIN, CHRIS WILLIS, RENU BHARDWAJ, ABIZER HARIANAWALA, JIANMEI KOCHLING, JUDITH PETERSCHMITT, DIANE P COPELAND, JOHN MARSHALL, JEFFREY SKELL, GERARD PALACE
• Format: Patent
• Language: English; Japanese
• Published: 26.11.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide: salt forms of a compound of formula (I), which is a GlcCer synthase inhibitor currently in clinical trials for the treatment of Gaucher disease, the salt forms being crystalline and otherwise having physical properties that are amenable to large scale manufacture; improved treatment methods utilizing the compound; and so on.SOLUTION: The present invention provides single crystalline forms of the formula (I) hemitartrate, methods of producing the salt, the use of the same, and pharmaceutical compositions containing the salt. 【課題】ゴーシェ病の治療のために、現時点で臨床試験中のＧｌｃＣｅｒシンターゼ阻害剤である式（Ｉ）の化合物の、結晶質および他の状態で大規模な製造に受け入れられる物理的特性を有する塩の形態、および該化合物を使用する改良された治療方法などの提供。【解決手段】式（Ｉ）・ヘミ酒石酸塩の単一の結晶型、該塩を製造する方法、その使用、及び該塩を含む医薬組成物。【選択図】なし