LOX AND LOXL2 INHIBITORS AND USES THEREOF

PROBLEM TO BE SOLVED: To provide anti-LOX (lysyl oxidase) and anti-LOXL2 antibodies about LOX or LOXL (lysyl oxidase-like) proteins for diagnosing and treating cancer.SOLUTION: Anti-LOX and anti-LOXL2 antibodies can be used against cancer to identify and treat conditions such as a fibrotic condition...

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Main Authors GARCIA CARLOS AURELIO, BARRY VIVIAN E, MARSHALL DEREK, BIERMANN DONNA HIROKO TOKUOKA, VAN VLASSELAER PETER, HOLZER ALISON KAY, OYASU MIHO, SMITH VICTORIA, OGG SCOTT, MCCAULEY SCOTT ALAN, RODRIGUEZ HECTOR
Format Patent
LanguageEnglish
Japanese
Published 26.11.2015
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To provide anti-LOX (lysyl oxidase) and anti-LOXL2 antibodies about LOX or LOXL (lysyl oxidase-like) proteins for diagnosing and treating cancer.SOLUTION: Anti-LOX and anti-LOXL2 antibodies can be used against cancer to identify and treat conditions such as a fibrotic condition, angiogenesis, or to prevent a transition from an epithelial cell state to a mesenchymal cell state. 【課題】癌の診断および治療のための、リシル・オキシダーゼ（ＬＯＸ）またはリシル・オキシダーゼ様（ＬＯＸＬ）タンパク質に関する抗ＬＯＸ抗体および抗ＬＯＸＬ２抗体の提供。【解決手段】癌に対して、抗ＬＯＸ抗体および抗ＬＯＸＬ２抗体を用いて、線維化状態、血管新生などの状態を同定および治療するか、または上皮細胞状態から間葉細胞状態への移行を防止することができる。【選択図】図６
Bibliography:Application Number: JP20150125989