METHOD FOR PRODUCING METHYL{4,6-DIAMINO-2-[1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDINE-3-YL]PYRIMIDINE-5-YL} METHYLCARBAMATE AND ITS PURIFICATION FOR USE THEREOF AS PHARMACEUTICALLY ACTIVE SUBSTANCE

• Main Authors: FRANZ-JOSEF MAIS, REHSE JOACHIM, WINFRIED JOENTGEN, KONRAD SIEGEL
• Format: Patent
• Language: English; Japanese
• Published: 19.11.2015
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a method for producing methyl{4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidine-5-yl} methylcarbamate (I).SOLUTION: This invention provides a method for synthesizing a compound of formula (I) by a pyridine-free reaction between formula (VIII) and methyl chloroformate or dimethyl dicarbonate and further a reaction with a methylation agent. 【課題】メチル｛４，６−ジアミノ−２−［１−（２−フルオロベンジル）−１Ｈ−ピラゾロ［３，４−ｂ］ピリジン−３−イル］ピリミジン−５−イル｝メチルカルバメート（Ｉ）の調製方法の提供。【解決手段】式(ＶＩＩＩ)とクロロギ酸メチル又は二炭酸ジメチルとをピリジン・フリー反応させ、更にメチル化剤を反応させて、式（Ｉ）の化合物を合成する方法。【選択図】なし