AMANTADINE COMPOSITIONS AND METHODS OF USE

• Main Authors: EFRAIM SHEK, MICHAEL COFFEE, ASHOK KATDARE, GAYATRI SATHYAN, GREG WENT, KAVITA VERMANI, GANGADHARA GANAPATI
• Format: Patent
• Language: English; Japanese
• Published: 23.07.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide extended release compositions of amantadine and methods of use.SOLUTION: Methods of nighttime administration of amantadine to reduce sleep disorders in a patient undergoing treatment with amantadine are described, as well as compositions of extended release amantadine that are suitable for nighttime administration. A method of administering amantadine to a patient in need thereof comprises orally administering an extended release (ER) composition comprising amantadine or a pharmaceutically acceptable salt thereof less than three hours before bedtime (i.e., the time at which the subject wishes to go to sleep for night). 【課題】アマンタジンの持続性放出組成物及び使用方法の提供。【解決手段】アマンタジンでの処置を受ける患者における睡眠障害を軽減するためのアマンタジンの夜間投与方法。夜間投与に適切な持続放出アマンタジンの組成物。アマンタジンを必要とする患者に投与する方法であって、アマンタジン又はその薬学的に許容され得る塩を含む持続放出（ＥＲ）組成物を就寝時刻より前の３時間未満（すなわち、被験体が夜に就寝を望む時間）に経口投与する工程を含む、方法。【選択図】なし