SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

• Main Authors: SVEN FRANCISCUS ANNA VAN BRANDT, WU TONGFEI, MICHEL SURKYN, FREDERIK JAN RITA ROMBOUTS, FRANCOIS PAUL BISCHOFF, GARRETT BERLOND MINNE, SERGE MARIA ALOYSIUS PIETERS, HENRICUS JACOBUS MARIA GIJSEN, DANIEL OEHLRICH, ADRIANA INGRID VELTER, MICHEL ANNA JOZEF DE CLEYN, DIDIER JEAN-CLAUDE BERTHELOT
• Format: Patent
• Language: English; Japanese
• Published: 16.07.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide: compounds useful as gamma secretase modulators applicable to Alzheimer's disease, traumatic brain injury, mild cognitive impairment, senility, dementia, dementia with Lewy bodies, cerebral amyloid angiopathy, multi-infarct dementia, Down's syndrome, dementia associated with Parkinson's disease, dementia associated with beta-amyloid, and the like; and pharmaceutical compositions comprising the compounds.SOLUTION: The present invention concerns substituted triazole and imidazole derivatives represented by formula (I) such as 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-N-(2-methylphenyl)-1H-1,2,4-triazol-5-amine. 【課題】アルツハイマー病、外傷性脳損傷、軽度認識障害、老衰、認知症、レヴィー小体認知症、脳アミロイド血管症、多発脳梗塞性認知症、ダウン症、パーキンソン病と関連する認知症及びベータ−アミロイドと関連する認知症などに適用できるガンマセクレターゼモジュレーターとして有用である化合物、該化合物を含んでなる製薬学的組成物の提供。【解決手段】３−［３−メトキシ−４−（４−メチル−１Ｈ−イミダゾール−１−イル）フェニル］−１−メチル−Ｎ−（２−メチルフェニル）−１Ｈ−１，２，４−トリアゾール−５−アミンのような式（Ｉ）で表される置換されたトリアゾール及びイミダゾール誘導体。【選択図】なし