ORALLY DISINTEGRABLE TABLET CONTAINING MIRTAZAPINE

• Main Authors: KWON TAE HOON, KIM YOUNG RAN, KAM SUNG HOON, LEE KYU HYUN, CHOI KYU SANG
• Format: Patent
• Language: English; Japanese
• Published: 16.07.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide Mirtazapine orally disintegrable tablets which are excellent in general easiness of ingestion such as without foreign body sensation and granular sensation, have high hardness so that a tablet is not damaged by packing, handling, and a distribution process, rapidly disintegrate in the oral cavity while having high hardness, and have an excellent storage stability.SOLUTION: The orally disintegrable tablet containing Mirtazapine, Mirtazapine particles, a sugar, sugar alcohol, or microcrystalline cellulose whose core is coated with Mirtazapine, or a sugar, sugar alcohol, or microcrystalline cellulose whose core is coated with other drugs contains mannitol as a main filler, and contains crospovidone together with sodium carboxymethyl starch as a disintegrator. 【課題】異物感がなくざらざら感がないなど全体的な服用感に優れ、包装、取り扱い、流通過程で錠剤が破損されないように高い硬度を有し、高い硬度を有しながらも口腔内で迅速に崩壊し、保存安定性に優れるミルタザピン口腔内崩壊錠の提供。【解決手段】ミルタザピン、ミルタザピン粒子、ミルタザピンがコーティングされた糖、糖アルコールまたは微結晶セルロースのコア、または他の薬物がコーティングされた糖、糖アルコールまたは微結晶セルロースのコアを含む口腔内崩壊錠において、主要充填剤としてマンニトールを含み、崩壊剤としてクロスポビドンと澱粉グリコール酸ナトリウムを共に含むことを特徴とする。【選択図】なし