PROCESSES FOR PRODUCING MONOAMMONIUM SUCCINATE FROM FERMENTATION BROTHS CONTAINING DIAMMONIUM SUCCINATE, MONOAMMONIUM SUCCINATE AND/OR SUCCINIC ACID, AND CONVERSION OF MONOAMMONIUM SUCCINATE TO SUCCINIC ACID

• Main Authors: BRIAN T KEEN, NYE A CLINTON, DILUM DUNUWILA, OLAN S FRUCHEY, BERNARD D DOMBEK, BROOKE A ALBIN
• Format: Patent
• Language: English; Japanese
• Published: 02.07.2015
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a method for producing substantially pure MAS directly from a fermentation broth comprising DAS, MAS, and/or SA.SOLUTION: The invention provides a method for producing MAS from a clarified DAS-containing fermentation broth comprising (a) distilling a broth to form an overhead comprising water and ammonia, as well as a liquid bottoms comprising MAS, at least some DAS, and at least about 20% of water; (b) cooling and/or evaporating the liquid bottoms, as well as optionally adding an antisolvent into the liquid bottoms to achieve a sufficient temperature and composition for separating the liquid bottoms into DAS-containing liquid portion and substantially DAS-free MAS-containing solid portion;(c) separating the solid portion from the liquid portion, and (d) collecting the solid portion. 【課題】ＤＡＳ、ＭＡＳ、及び／又はＳＡを含む発酵培地から、実質的に純粋なＭＡＳを直接製造する方法の提供。【解決手段】清澄化ＤＡＳ含有発酵培地からＭＡＳを製造する方法であって、（ａ）水とアンモニアとを含む上部（overhead）、並びに、ＭＡＳと、少なくとも幾らかのＤＡＳと、少なくとも約２０％の水とを含む液体底部（liquid bottoms）を形成するために培地を蒸留し、（ｂ）底部を、ＤＡＳ含有液体部分と、実質的にＤＡＳを含まないＭＡＳ含有固体部分とに分離させるのに十分な温度及び組成を達成するために、底部を冷却及び／又はエバポレートし、並びに任意により、底部へ逆溶媒を添加し、（ｃ）液体部分から固体部分を分離し、（ｄ）固体部分を回収することを含む方法。【選択図】図１