AZAINDOLE USEFUL AS JAK AND OTHER PROTEIN KINASE INHIBITOR

• Main Authors: EVERITT SIMON, BOYALL DEAN, BETHIEL RANDY, COME JON, LAUFFER DAVID, SALITURO FRANCESCO, ROBINSON DANIEL, HARRINGTON EDMUND, BINCH HAYLEY, FARMER LUC, MORTIMORE MICHAEL, WANG JIAN, ARONOV ALEX, PIERARD FRANCOISE, PIERCE ALBERT, GREEN JEREMY, CHARRIER JEAN-DAMIEN, COURT JOHN, PINDER JOANNE, WANG TIANSHENG, FRAYSSE DAMIEN
• Format: Patent
• Language: English; Japanese
• Published: 22.06.2015
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a JAK and other protein kinase inhibitor.SOLUTION: Provided is a compound of the formula (I) that is an inhibitor of protein kinase. Also provided are a pharmaceutical composition containing said compound and a method for using said composition in the treatment of various disorders. Now said compound and pharmaceutically acceptable composition thereof are found effective as the inhibitor of JAK, ROCK and Aurora protein kinase. In one embodiment, these compounds are effective as inhibitor of JAK, ROCK and Aurora protein kinase. 【課題】ＪＡＫおよび他のプロテインキナーゼの阻害剤を提供する。【解決手段】本発明は、プロテインキナーゼの阻害剤である式（Ｉ）の化合物に関する。本発明はまた、本発明の化合物を含有する医薬組成物および種々の障害の治療においてこれらの組成物を使用する方法を提供する。現在、本発明の化合物およびそれらの薬学的に受容可能な組成物は、ＪＡＫ、ＲＯＣＫおよびＡｕｒｏｒａプロテインキナーゼの阻害剤として有効であることが発見された。ある実施態様では、これらの化合物は、ＪＡＫ、ＲＯＣＫおよびＡｕｒｏｒａプロテインキナーゼの阻害剤として有効である。【選択図】なし