PERCUTANEOUS ABSORPTION PREPARATION, AND ADHESIVE SHEET FOR SKIN PATCH

• Main Authors: OGINO HIROYUKI, YUKIMOTO SADAO, HAMADA MITSUYO, AKAZAWA MITSUJI, GOTO MASAOKI
• Format: Patent
• Language: English; Japanese
• Published: 22.06.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PROBLEM TO BE SOLVED: To provide an adhesive sheet for skin patch having low skin irritation while having sufficient adhesiveness, and to provide a percutaneous absorption preparation having a sufficient drug release property in addition to the above properties.SOLUTION: The invention provides an adhesive sheet for skin patch in which an adhesive layer is formed on a support material. The adhesive layer comprises at least a thermoplastic elastomer and a nonvolatile hydrocarbon oil of more than 50 parts by weight to 800 parts by weight or less against 100 parts by weight of the elastomer. And a kinematic viscosity at 40°C of the nonvolatile hydrocarbon oil thereof is 80 mm/s or more. The invention also provides a percutaneous absorption preparation obtained by allowing the adhesive layer to contain a drug or a pharmaceutically acceptable salt thereof. 【課題】十分な粘着性を有しながら皮膚刺激性の低い皮膚貼付用粘着シートを提供すること。さらには、上記特性に加えて十分な薬物の放出性を有する経皮吸収製剤を提供すること。【解決手段】支持体上に粘着剤層が形成された皮膚貼付用粘着シートであって、前記粘着剤層は少なくとも熱可塑性エラストマー、該エラストマー１００重量部に対して５０重量部を超え、８００重量部以下の不揮発性炭化水素油を含み、かつその不揮発性炭化水素油の４０℃における動粘度が８０ｍｍ２／ｓ以上である、皮膚貼付用粘着シート。さらには該粘着層に、薬物またはその薬学的に許容し得る塩を含有せしめてなる経皮吸収製剤。【選択図】なし