TRANSITION METAL-CATALYZED PROCESS FOR PREPARATION OF N-ALLYL COMPOUND AND USE THEREOF

PROBLEM TO BE SOLVED: To provide a process for the N-dealkylation of a tertiary amine.SOLUTION: A method for preparing an N-allyl compound from a tertiary amine comprises converting a tertiary amine into an allyl carbamate, followed by carrying out decarboxylation in a transition metal-catalyzed rea...

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Bibliographic Details
Main Authors SERGIO SANDOVAL, KEITH E MCCARTHY, JAKE L STYMIEST, JOSHUA R GIGUERE, HELGE A REISCH
Format Patent
LanguageEnglish
Japanese
Published 11.06.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PROBLEM TO BE SOLVED: To provide a process for the N-dealkylation of a tertiary amine.SOLUTION: A method for preparing an N-allyl compound from a tertiary amine comprises converting a tertiary amine into an allyl carbamate, followed by carrying out decarboxylation in a transition metal-catalyzed reaction. A method for preparing a compound as given below comprises bringing the N-allyl compound into contact with an allyl scavenger and a transition metal catalyst. (R14 and R16 each independently represent -OH, -H, or -OR17; R15 represents -OH, -H, -OR17, =O, or =CH2; and R17 represents an oxygen protective group). 【課題】第３級アミンのＮ−脱アルキル化のためのプロセスの提供。【解決手段】第３級アミンからカルバミン酸アリルへの変換、次いで、遷移金属触媒反応において脱カルボキシル化を行い第３級アミンからＮ−アリル化合物を調製する方法、および該Ｎ−アリル化合物をアリルスカベンジャー及び遷移金属触媒と接触させて、下記化合物を調製する方法。(Ｒ１４及びＲ１６が各々独立に−ＯＨ、−Ｈ又は−ＯＲ１７；Ｒ１５が−ＯＨ、−Ｈ、−ＯＲ１７、＝Ｏ又は＝ＣＨ２；Ｒ１７が酸素保護基）【選択図】なし
Bibliography:Application Number: JP20140262237