BENZOAZOLYLPIPERAZINE DERIVATIVE HAVING mGluR1- AND mGluR5-ANTAGONIST ACTIVITY

• Main Authors: VICTORY SAM, SUN QUN, TAFESSE LAYKEA
• Format: Patent
• Language: English; Japanese
• Published: 30.04.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a method for treating or preventing pain, urge urinary incontinence (UI), ulcers, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), dependent disorders, Parkinson's disease, parkinsonism, anxiety, epilepsy, seizure, convulsion, pruritic symptom, psychosis, cognitive disorder, memory deficiency, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia, retinopathy, muscle cramp, migraine, vomiting, dyskinesia or depression.SOLUTION: Provided are: a compound represented by the following formula or a pharmaceutically acceptable salt thereof ("benzoazolylpiperazine compound"); and a composition comprising a benzoazolylpiperazine compound (Aris benzothiazolyl, benzoxazolyl or benzoimidazolyl group). 【課題】疼痛、切迫尿失禁(UI)、潰瘍、炎症性腸疾患(IBD)、過敏性腸症候群(IBS)、依存性障害、パーキンソン病、パーキンソン症候群、不安症、癲癇、発作、痙攣、そう痒性症状、精神病、認知障害、記憶欠乏、制限性脳機能、ハンティングトン舞踏病、筋萎縮性側索硬化(ALS)、痴呆、網膜症、筋痙攣、偏頭痛、嘔吐、運動異常またはうつ病を治療または予防する方法の提供。【解決手段】下記式で表される化合物、またはその製薬上許容可能な塩(「ベンゾアゾリルピペラジン化合物」)、ベンゾアゾリルピペラジン化合物を含む組成物。(Ar2はベンゾチアゾリル、ベンゾオキサゾリル、又はベンゾイミダゾリル基)【選択図】なし