NUCLEIC ACID AND CORRESPONDING PROTEIN NAMED 158P1D7 USEFUL IN TREATMENT AND DETECTION OF BLADDER CANCER AND OTHER CANCERS

• Main Authors: CHALLITA-EID PIA M, RAITANO ARTHUR B, MORRISON KAREN JANE MEYRICK, KANNER STEVEN B, FARIS MARY, PEREZ-VILLAR JUAN J, GE WANGMAO, GUDAS JEAN, MORRISON ROBERT KENDALL, JAKOBOVITS AYA
• Format: Patent
• Language: English; Japanese
• Published: 26.03.2015
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; TRAPPING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a novel gene (designated 158P1D7) and its encoded protein.SOLUTION: While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers shown in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or a fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response. 【課題】１５８Ｐ１Ｄ７と命名された新規な遺伝子及びそのコードするタンパク質を開示する。【解決手段】１５８Ｐ１Ｄ７は正常成人組織においては組織特異的な発現を示すが、表１に示した複数の癌において異常に発現される。従って、１５８Ｐ１Ｄ７は癌の診断及び／又は治療のための標的を提供する。１５８Ｐ１Ｄ７遺伝子若しくはそのフラグメント、又はそのコードするタンパク質若しくはそのフラグメントは免疫応答を誘発するために用いることができる。【選択図】なし