MAMMALIAN INTERLEUKIN-12 P40 AND INTERLEUKIN B30, COMPOSITIONS THEREOF, ANTIBODIES, AND USE IN PHARMACEUTICAL COMPOSITIONS

• Main Authors: KASTELEIN ROBERT A, RENNICK DONNA M, NARULA SATWANT K, DE WAAL MALEFYT RENE, OPPMANN BIRGIT, WIEKOWSKI MARIA T, LIRA SERGIO A
• Format: Patent
• Language: English; Japanese
• Published: 19.03.2015
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide purified genes encoding mammal-derived cytokine, reagents related to the gene including purified proteins, specific antibodies, and nucleic acids encoding the molecule.SOLUTION: Provided are: a purified gene encoding a cytokine from a mammal; and reagents related to the gene including purified proteins, specific antibodies and nucleic acids encoding the molecule. Also provided are a method for using these reagents and diagnosis kits. The invention, in particular, relates to a composition comprising a combination of interleukin-B30 (IL-B30) and IL-12p40 subunit, and the biological activities thereof. It includes nucleic acids encoding both polypeptides or fusion proteins, and the methods for their production and use. 【課題】哺乳動物由来のサイトカインをコードする精製された遺伝子、精製されたタンパク質、特異的抗体を含むこの遺伝子に関連する試薬、およびこの分子をコードする核酸を提供すること。【解決手段】哺乳動物由来のサイトカインをコードする精製された遺伝子、精製されたタンパク質、特異的抗体を含むこの遺伝子に関連する試薬、およびこの分子をコードする核酸が提供される。これらの試薬を使用する方法および診断キットもまた提供される。本発明は、特に、インターロイキン−Ｂ３０（ＩＬ−Ｂ３０）とのＩＬ−１２ｐ４０サブユニトの組み合わせを含む組成物およびそれらの生物学的活性に関し、ポリペプチドまたは融合タンパク質の両方の核酸コードならびにそれらの産生および使用の方法を含む。【選択図】なし