2-AMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS

• Main Authors: MAKTAIS FRANCOIS, MORTIMORE MICHAEL, DAVIS CHRIS, BOYALL DEAN, BEMIS GUY, SETTIMO LUCA, YOUNG STEVEN, JUAN-MIGUEL JIMENEZ, WANG TIANSHENG, KNEGTEL RONALD, FRAYSSE DAMIEN
• Format: Patent
• Language: English; Japanese
• Published: 05.02.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide 2-aminopyridine derivatives useful as kinase inhibitors.SOLUTION: The present invention relates to compounds represented by the structural formula (I) useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds and methods of using the compositions in treatment of various disease, conditions or disorders. The invention also provides methods for preparing compounds of the inventions. In one embodiment, the invention provides a method of treating or preventing a protein kinase-mediated condition in a subject. 【課題】キナーゼ阻害剤として有用な２−アミノピリジン誘導体を提供すること。【解決手段】本発明は、プロテインキナーゼの阻害剤として有用な、構造式（I）で示される化合物に関する。また、本発明は、該化合物を含む医薬上許容される組成物、および種々の病気、疾患または障害の治療において該組成物を用いる方法にも関する。また、本発明は、本発明の化合物を調製する方法も提供する。１つの実施形態において、本発明は、対象においてプロテインキナーゼ媒介疾患を治療または予防する方法である。【選択図】なし