HYALURONIC ACID BASED COPOLYMERS

• Main Authors: HOSSAINY SYED F A, CONNIE KWOK, PACETTI STEPHEN D, GLAUSER THIERRY, MICHAEL EUGENE
• Format: Patent
• Language: English; Japanese
• Published: 15.01.2015
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP

PROBLEM TO BE SOLVED: To provide a composition for decreasing stent thrombosis and restenosis, and to provide an implantable device using the same.SOLUTION: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, intermittent claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof. 【課題】ステント血栓症及び再狭窄を軽減する組成物及びそれを用いた埋め込み型用具を提供する。【解決手段】埋め込み型用具をコートするためのヒアルロン酸（ＨＡ）抱合体又は架橋ＨＡの組成物が提供される。アテローム性硬化症、血栓症、再狭窄、高コレステロール、出血、血管の切開又は穿孔、動脈瘤、不安定プラーク、慢性全閉塞、間欠性跛行、静脈及び人工移植片の吻合部の増殖、胆管閉塞、尿管閉塞、腫瘍閉塞及びこれらの組み合わせのような障害を治療するために該埋め込み型用具を使用することができる。【選択図】図１