COMPOSITION AND METHOD FOR TREATMENT OF DIABETIC RETINOPATHY

• Main Authors: JOHN BURNIER, THOMAS GADEK, CHARLES SEMBA
• Format: Patent
• Language: English; Japanese
• Published: 27.11.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide methods of treating diabetic retinopathy.SOLUTION: This invention relates to methods of treating diabetic retinopathy, comprising administering an effective amount of a therapeutic agent which inhibits the interaction of a lymphocyte function-associated antigen-1 (LFA-1) and an intercellular adhesion molecule-1 (ICAM-1). Preferably, in the methods of treating, an effective amount of an LFA antagonist is administered. A preferable LFA antagonist is a compound represented by the following formula. 【課題】糖尿病性網膜症を治療する方法の提供。【解決手段】リンパ球機能関連抗原−１（ＬＦＡ−１）及び細胞内接着分子−１（ＩＣＡＭ−１）の相互作用を阻害する有効量の治療薬を投与する、糖尿病性網膜症の治療方法。該治療方法において、有効量のＬＦＡアンタゴニストを投与することが好ましい。ＬＦＡアンタゴニストとしては、下式を代表例とする化合物であることが好ましい。【選択図】なし