CASPASE-1 ACTIVATION INHIBITOR, ANTI-INFLAMMATORY AGENT, ANTIPRURITIC AGENT, AND EVALUATION METHOD OF CASPASE-1 ACTIVATION INHIBITOR

PROBLEM TO BE SOLVED: To provide a caspase-1 activation inhibitor which inhibits the activation of caspase-1 efficiently, and to provide an anti-inflammatory agent and an antipruritic agent which can effectively treat inflammation, itch or the like using the caspase-1 activation inhibitor concerned....

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Bibliographic Details
Main Authors TAKEMORI HIROSHI, FUCHINO HIROYUKI, ITO YUMI, SANOSAKA MASATO, KAWAHARA NOBUO
Format Patent
LanguageEnglish
Japanese
Published 17.11.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a caspase-1 activation inhibitor which inhibits the activation of caspase-1 efficiently, and to provide an anti-inflammatory agent and an antipruritic agent which can effectively treat inflammation, itch or the like using the caspase-1 activation inhibitor concerned.SOLUTION: A caspase-1 activation inhibitor regulates a mitochondrial oxygen consumption, has a hypoglycemic action, and is at least one kind selected from pterosin B, pterosin Z, acetyl-pterosin B, pterosin F, and metformin. 【課題】カスパーゼ１の活性化を効率的に阻害するカスパーゼ１活性化阻害剤、当該カスパーゼ１活性化阻害剤を用いた炎症や痒み等を効果的に治療することができる抗炎症剤及び鎮痒剤を提供する。【解決手段】ミトコンドリアの酸素消費を調節し、血糖降下作用を有するカスパーゼ１活性化阻害剤であって、プテロシンＢ、プテロシンＺ、アセチル−プテロシンＢ、プテロシンＦ、及びメトホルミンの中から選択される少なくとも１種のカスパーゼ１活性化阻害剤である。【選択図】図５
Bibliography:Application Number: JP20130094995