MAGNETIC PARTICLES AND METHOD FOR PRODUCING THE SAME

• Main Authors: HASEGAWA AKIKO, MIYAMORI MASAMITSU
• Format: Patent
• Language: English; Japanese
• Published: 13.11.2014
• Subjects: CHEMISTRY; COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSESC01D OR C01F; HUMAN NECESSITIES; HYGIENE; INORGANIC CHEMISTRY; MEDICAL OR VETERINARY SCIENCE; METALLURGY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PROBLEM TO BE SOLVED: To provide magnetic particles which enhance immunoreactivity without reducing its particle diameter.SOLUTION: The magnetic particles contain superparamagnetic metal oxide particles (C) having an average particle diameter of 1-15 nm in a non-magnetic metal oxide (D). The superparamagnetic metal oxide particles (C) are contained in an amount of 60-95 wt.% based on the total weight of the superparamagnetic metal oxide particles (C) and the non-magnetic metal oxide (D). The magnetic particles have an average particle diameter of 1-5 μm, a shape factor SF1 of 101-200, and a shape factor SF2 of 110-220. Preferably, the non-magnetic metal oxide (D) is at least one selected from the group consisting of silicon oxide, titanium oxide, zirconium oxide, aluminum oxide, calcium oxide, yttrium oxide, and tantalum oxide, and the superparamagnetic metal oxide particles (C) are made of iron oxide. 【課題】本発明の目的は、粒子径を小さくすることなく、免疫反応性を高める磁性粒子を提供することにある。【解決手段】平均粒子径が１〜１５ｎｍの超常磁性金属酸化物粒子（Ｃ）を非磁性金属酸化物（Ｄ）中に含有し、（Ｃ）と（Ｄ）の合計重量に対して（Ｃ）を６０〜９５重量％含有してなる磁性粒子であって、該磁性粒子の平均粒子径が１〜５μｍであり、かつ形状係数ＳＦ１が１０１〜２００であり、かつ形状係数ＳＦ２が１１０〜２２０である磁性粒子。（Ｄ）が、酸化ケイ素、酸化チタン、酸化ジルコニウム、酸化アルミニウム、酸化カルシウム、酸化イットリウムおよび酸化タンタルからなる群から選ばれる少なくとも１種であり、（Ｃ）が酸化鉄からなる粒子であることが好ましい。【選択図】なし